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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '581d9c49bb880e7c7e3fc8554519128d31a014e9ed57851057872d9c2f56acf5' 
  AND token = 'KEhMAdSI5U+nl9arYVePv4pCGPD6IccvdyJ3AbdpjMg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}