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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d42be74739515ca6e0e674c5f8325dd83aa4fac81a2592dd9f025570571d0ec' 
  AND token = 'VJUG1pcgCiJ54B41h99XnkMommGctCO3DRdRdwrTu/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}