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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5295e2ee21bf98ae4f0bdc31397416d6cdab1aefae5432966e46f2a5c62deff8' 
  AND token = 'gDMqoW5HnL1ygRPu/3i+oazb5x6gVmBcUBmu39EUVuU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}