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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '111dfa374ad430305da24de65dafd40c5b15aa0d272c676b9918d45915d9330b' 
  AND token = 'TGRt+6C8eNfQRpDXAx24SPlrgM8ho5Yp1kKaP4XjTsU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}