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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cf81ea19d185eed01d09acb30819233b739523fcbadf57b5a14fc39dd9a15285' 
  AND token = 'LONGPvOnxTUiY00V44k2u8+OmPJju8OwuPbY3V0okCc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}