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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '648c46f09bdc6f84f0a67543a976a7a220062684b080089a04cfb76fb4b7a32d' 
  AND token = '5/OpiJZKCSIoDLHfuGQLezA1soGmj9JQRnTd5kYtWbI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}