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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '419c611e2134522f666df61068d67b5e66566910a22327da3b94eb9d0e3365f4' 
  AND token = 'GP26NA4BUoCtcZmSxDbeiV2b1xtIwBz/FrreZP5rQvQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}