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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49fea399a822cd0475d0d6fd154c4ad8bcfefe018cc2358f2ea738735dff4369' 
  AND token = 'CBsHSMW2n8FeVGWMIshnJSCqPV4tpSQ4fUF2mN0hSMs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}