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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e66e2ff38068b4c6fe8f8e5283227c3143382e222375d6a409da0b804bc94ceb' 
  AND token = '78APTHoG4OOePs7tB64y9e+heIYTXsjjxbaOHhaPpNI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00040

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}