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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '154e3ad3ba7c0562a811a5bb0d58fcbbb609f22e605d227907bb7327d9651c05' 
  AND token = 'D2ZozNUL9PwXAKtbi89dJN3c6NCaIMZSaY5PWoibVkQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}