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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '749ad2f7979c71e1e7dea6cee2204b49f43c5c01af3cbf394bdf48ebb33dd979' 
  AND token = 'PEIkLpdqkwEBVOCdmTeRxmzDux5a9mA6HDXTiLSkVbc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}