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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '929d45aa2156d3a4c79dd493526c8b9c15ea50bc13265a1e1e609bf9859c6c45' 
  AND token = 'tmXdjftfILxLmmh+NphVvSkpf/g+W6GXD6syW4h7Hfc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}