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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '448933c8f3dc43623bbcea58a7e7f1e29079d906e53a24629e3ee7993b314c21' 
  AND token = 'EIOdn3yLHFKSYe0hinmz4Mo4Yqe392vEcQsuTXS8DZs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}