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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'be7b186cf1379ff6f292a89f10d96c0cbe739df2372ecc883c6387378ae00016' 
  AND token = 'uqOoSA1wzf6ncqf6H+fkdQxqgQJqpGdZQCJ3cbWANu4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}