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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f953e05b99bd9a80678f91bb517d2344a43e16d22ba8230196b98907482b9d0a' 
  AND token = '379zzUHOSxRyOdtbAaV6vIkCoyqMAMtJBhkUZC8SeBA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}