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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1eab2ad6baa9eaedf3228df8c42330a81c28a14ed201987d1d68c735ed83b2ff' 
  AND token = 'S+mRpK/vBspesJ+ON1zldwdEUC2ZTuK2bSDfOnD+0Jo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}