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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a426e21c6ac6c1cc47c7daef2d86dd53332cd6b2f816024f9e854842bd21dcbb' 
  AND token = 'YmOT/RcBUpY6xRn/Cy7C7oNMVsJWQEvh3d2E0iMUxjE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}