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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f0ea7158bbbffef330e0ee5a9ea1d35ab38317b572e073c8f3e3c101b4994402' 
  AND token = 'Gp8cY3z0UFWTfUxj7nprEqX1ehVmRBmnFRB36N0M1XM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}