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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '82ad4b54a27d9105cae1c9e29cb08c88d83c9c095ca49429339938687c01e890' 
  AND token = 'jw/bVQr7XzW6WO2v2Wd6YzWp5keWm/fncLPdtTFtPJI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}