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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '28649ec035589efce78e2e4ffff4a3826040937421efbad2a8f59a867d2f0ce9' 
  AND token = 'NZ9QJTDe04CpuBTc9QGr8TEthCw2YcCmH4M5ztxi7Nc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}