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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e45fd3be0e1144f4ae4d47be277c25bc8d27a3c965850a2d8c413302de83ba22' 
  AND token = 'MIQMe4fzO84o85Fw2f6tt9o50mQPO2Nli48ram+lBjY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}