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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a3c61449316f46f98120e0bd21d2f3d1d0a1a624d142ca6938ff92aee4bb3271' 
  AND token = 'smqMmMkQigjNHj+T+MENMZC7vF6SQRIEjBbPNMVnD+U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}