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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54f9057944a3d46eace8b51cd491efdc0400e3c39b2c038656b2528cff4daebc' 
  AND token = 'X78S2yt36gKsuLYXgf+V1st/fe75TxHoaPj6DvciNFc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}