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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ae2b9351f197ddf016dfc8864da25fb671bdddc1e84a16969ced8a1c87c76067' 
  AND token = 'kupZVAolwBtNIMaI+4EXVB/unus67trTTECgbi1WXss=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}