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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b324dd21034a56d6f5f2905b66e6f0640db315c0f439f7a2546e567f721adb49' 
  AND token = 'T0XhnEvRj3QxSv9rbW5/+N3u+YAH494Y5PWEJaNfJEE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}