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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f43919d6fe6a45098ecfb40ea487f7cfdf0aca4511890c7d439b3f02a2677144' 
  AND token = 'BJoOhp0mxZbHE/PJ6oUMsiQQmvizBKbxvO4PEU12XfQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}