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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f440e0929ba5848495d4937250a5185bd4ed25b74e4f59ae6f63145f04011c0c' 
  AND token = 'hS8FxrV42fApCL811kaWVUCRvvDUBGofa2ObLmv9/Vk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}