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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ac1f6545a1f9eb0d5686f5311a222389b82c8817e0223611c6dd37a2beb5f71' 
  AND token = 'S8af3PIW0LPlxVNyA0HtyOZZbWNGL5lV1yQ2aiwZrdc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}