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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46201431a7d011a806106a674f6abeed160d005b2c3a678ac21af7992f147414' 
  AND token = 'fUjV4k/aN4LzElzft8Ew4kLIfARbpI17yXvREQpUBDY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}