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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b2a53b68ecfebd750c7a1ed2a1a71bda42b7336872201ad3578baa2ea8178c2' 
  AND token = 'G6nq0MjvHbkDPkrG+IXRnFx4s+h0KKnmfLoPqWAXWoY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}