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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57b149e91ca11e04d61ff3abc20181c3ebd7fb5ed8279fe6e74b021d6e3be645' 
  AND token = 'e7MUUHH9BbnnIKL5Qk+tziBdBakIKs4WYXhxxam/jlE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}