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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42f33d662a1e26c1e104490cc54ed66d78ed16a5c026475ff160d019adc5195b' 
  AND token = 'fkQccwUnKWyeNs3F3WDH6XE5SRlHsUCLnpQ9U1vQVg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}