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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0cfedc366d8a9892add6480bbda18265c42db7c42bdcc7c140f6693093263a16' 
  AND token = 'lYiYgcm1m/3Su/q6jqPdEcM+pEgt8Cac5uiGt3jCmEw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}