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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de14655d38d5516358ff602f9a6297d62cbeb3309fd1dc8ace40f4111da4f3fa' 
  AND token = 'kF0J36iMzkDSKMHTo3e9dcrzd1TxTv6mpgMZ/AH29dU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}