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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49fd8113c4a1d36c063c50a94a7c82b53b1fd164000831e3b996777ba19111d0' 
  AND token = 'D4uz0XTapHseUfFyIOhVyINEkheTO9p5U4D1voW5HUg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}