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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3dd63d2c1701da26bdbcd404c5176390514a034bb7f35a6bbdecd2bf28108398' 
  AND token = 'zUwxgyyWfCTHtPlMjPpEhXmHR/dg2XdThgjJ4IPteZo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}