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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6b168dbf9f0278b5c41b04509d5bacc16b05909531036018d0f7214ccc8e1df1' 
  AND token = 'DCZt/JAZN4I9EIThnfrU1akGtWyBtHbgIFD3FJ1kSIc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}