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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3fa25f61996b6c18f53e19872c0eceddef4181a722dcf8f07caa312de78d6ce4' 
  AND token = 'My+P/tg+2qyyPID9/5wmT71McHYd6e5nli8hrlB99r4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}