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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '494940ad63b3ea66d599a65a3f026d1a6564bf5d24bbb840bdf1c9d3048f8f81' 
  AND token = 't5aCH6wYhlRDg2yOnL6aQx9U8LQYKF5yCOWiR0ynS6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}