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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '73e291d2eac9a7e32e2304e5f610c46cef81e42ce2c75e9069982d7c1d4642b2' 
  AND token = 'KbIayZOP/4e/AMT+FT1tR1aSKYAwMa22gh1ZjFjyxV8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}