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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57cb17d25b3c8326c3b16081f1466b78131dc1a089588b357dfaf6e3486a3a05' 
  AND token = 'zDlh+P5SoYT/CodoMNe6GIKZf3wtt9NqjcyZdS1zEOo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}