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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de196be8436655c1372329b3af2236f25695ebf99eac2c27b2a700e758a353bc' 
  AND token = '+Fte7zTvV6vkTA2s7ZoXct9E18Lse0IlmFL1YzoYH/Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}