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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4221e9da3efea3196832ac038162da11a48c9b0bf7472094dc04c0f6b29fa75' 
  AND token = 'hMaZYTWfSKCKHqifrGmvP23mFXdkc/rRkZjRkXfxswI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}