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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8afec648a5f781582ab690b37ff09e61bc4d5e6336ff7be48efad9a788980c6' 
  AND token = 'sRUZ4iypiq3rwoi8ULzkMX4dDcOwntoHA68UQHxMlW4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}