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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '536492862ab240a363d2e4f2fb0339bbc90ec2574a0e1da3ffa048b4ce4debe4' 
  AND token = 'bPph0nL8wSWhEm/b4BtzbpPNw0g9k51yWZGYIzrw8jQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}