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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f78542091bc6cb8711b1c690fa4d525f01ddc06aa3c91f7a65da9031c7e5f59' 
  AND token = 'TgY3YabXVM6F0wGmamD7TX9jvaOuMdjw4v1CDkCXghM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}