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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7f9637b68c4a1afc0640f627b43aed488f1b875f1a4eb11597584e284c2a89d2' 
  AND token = 'm+Ltqk8/on5Q7kPO6UwqWHJTWwW+WUL0ESGHG91eua4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}