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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22012f8841c04607666a55ae242d052c301514a67501a3fd418a0309584566de' 
  AND token = '2XWBd37F1PeHAzU499x8gfrl5US2/+zm88BfBfIUCJI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}