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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4ed21f20740042f6576233e623b0e5ff79911b50533112072e1b4cb4d9bdbe5' 
  AND token = 'nzPyJfwu2Vk+g70Zm04+UVn++KsFK3+YyRR2Ytv6a/I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}