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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '376c10d8386eb88970643fb1a537e1415200281cf603faddb5de28bcf5090d99' 
  AND token = 'pT+sHJ0/vgiG/DqQ97lv/ALGR0yiSEdDE2SZ+19DEnM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}